Key result
Urokinase (12 or 24 hours) and streptokinase (24 hours) were more effective than heparin alone in accelerating the resolution of pulmonary emboli, with no significant difference in mortality.
Why the study?
Does thrombolytic therapy with urokinase or streptokinase accelerate the resolution of pulmonary thromboemboli compared to heparin alone in patients with pulmonary embolism?
Population
327 patients with a clinical history and angiographic diagnosis of pulmonary embolism.
Comparison
Urokinase or Streptokinase vs Heparin alone or active comparators
Design
RCT, Randomly allocated to treatment, All physicians making patient…
Follow-up
24-30 hours
Authors
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Thrombolytics accelerate PE resolution over heparin; supports medical therapy as embolectomy alternative without mortality benefit.
RCT (n=327)
Observer-blinded
Randomly allocated
Does thrombolytic therapy with urokinase or streptokinase accelerate the resolution of pulmonary thromboemboli compared to heparin alone in patients with pulmonary embolism?
Thrombolytic therapy with urokinase or streptokinase accelerates the resolution of pulmonary emboli compared to heparin alone, offering a medical alternative to pulmonary embolectomy.
William R. Bell (1976) conducted an RCT in Pulmonary embolism (n=327). Urokinase and Streptokinase vs. Heparin alone was evaluated on Resolution of the thromboembolism 24-30 hours after therapy. Urokinase (12 or 24 hours) and streptokinase (24 hours) were more effective than heparin alone in accelerating the resolution of pulmonary emboli, with no significant difference in mortality.
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