Why the study?
Does urokinase compared to heparin improve fibrinolysis and resolution of pulmonary emboli in patients with acute pulmonary embolism?
Population
30 patients with acute pulmonary embolism (n=30)
Comparison
Urokinase vs Heparin alone
Design
RCT, Randomized into three groups of 10 patients each
Follow-up
Up to 1 year
Authors
Loading...
No added benefit of urokinase over heparin for PE resolution; challenges routine fibrinolysis and supports anticoagulation alone.
Does urokinase compared to heparin improve fibrinolysis and resolution of pulmonary emboli in patients with acute pulmonary embolism?
Heparin alone may induce a lytic state similar to urokinase, with no significant differences observed in the clinical resolution of pulmonary emboli between the two treatments.
Marini et al. (2009) studied this question.