Why the study?
Does urokinase alternating with heparin improve angiographic outcomes compared to streptokinase in patients with acute iliofemoral thrombosis?
Population
n=33 patients with acute iliofemoral thrombosis
Comparison
Urokinase alternating with heparin for 12 hr… vs Streptokinase 250,000 I.U. in 20 min, followed…
Design
RCT, randomly assigned, blinded interpretation of pre- and post-treatment…
Follow-up
3 to 6 days
Authors
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No early angiographic advantage for urokinase over streptokinase; confirms limited resolution across regimens and supports larger safety trials.
Does urokinase alternating with heparin improve angiographic outcomes compared to streptokinase in patients with acute iliofemoral thrombosis?
Intermittent urokinase-heparin therapy did not show an advantage over streptokinase for thrombus resolution in acute iliofemoral thrombosis, though it was associated with fewer adverse reactions.
Loo et al. (1983) studied this question.
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