Why the study?
Does low-dose streptokinase combined with low-dose heparin improve safety or efficacy compared to high-dose streptokinase in patients with acute deep vein thrombosis of the thigh?
Population
80 patients with acute deep vein thrombosis (DVT) of the leg (thigh)
Comparison
Low-dose streptokinase in combination with… vs High-dose streptokinase (100,000 U/h)
Design
RCT, prospective randomized trial
Follow-up
mean 31 and 38 months respectively
Authors
Loading...
Low-dose streptokinase plus heparin increases harm without added efficacy in acute DVT; challenges dose-reduction strategies and supports high-dose regimens.
Does low-dose streptokinase combined with low-dose heparin improve safety or efficacy compared to high-dose streptokinase in patients with acute deep vein thrombosis of the thigh?
Low-dose streptokinase combined with heparin is inferior to high-dose streptokinase for acute DVT due to a higher risk of severe hemorrhagic complications and postthrombotic changes.
Schulman et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: