Why the study?
Does high dose streptokinase over 1 hour improve right ventricular dysfunction and pulmonary artery pressure compared to low dose streptokinase over 24 hours or anticoagulation alone in patients with submassive pulmonary embolism?
Population
60 patients with submassive pulmonary embolism and right ventricular dysfunction.
Comparison
High dose streptokinase administered over 1 hour. vs Low dose streptokinase administered over 24…
Design
RCT, Patients without contraindications to streptokinase were randomly…
Follow-up
72 hours
Authors
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Supports streptokinase over anticoagulation for submassive PE with RV strain; confirms high- and low-dose equivalence.
Does high dose streptokinase over 1 hour improve right ventricular dysfunction and pulmonary artery pressure compared to low dose streptokinase over 24 hours or anticoagulation alone in patients with submassive pulmonary embolism?
Both high-dose (1 hour) and low-dose (24 hours) streptokinase are equally effective in rapidly reversing right ventricular dysfunction and pulmonary hypertension in submassive pulmonary embolism, with a slightly higher bleeding risk in the high-dose group.
Abdelsamad et al. (2011) studied this question.
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