Why the study?
Does low-dose streptokinase combined with low-dose heparin improve long-term sequelae in patients with symptomatic calf vein thrombosis compared to heparin alone?
Population
36 patients with symptomatic calf vein thrombosis (CVT), verified by venography
Comparison
Low-dose streptokinase combined with low-dose… vs Heparin alone
Design
RCT, Randomized
Follow-up
average of 5 years
Authors
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Low-dose streptokinase adds no benefit over heparin for calf vein thrombosis; supports avoiding its use given hemorrhagic risks.
Does low-dose streptokinase combined with low-dose heparin improve long-term sequelae in patients with symptomatic calf vein thrombosis compared to heparin alone?
Low-dose streptokinase does not improve long-term sequelae of calf vein thrombosis compared to heparin and is not justified due to the risk of serious hemorrhagic side-effects.
Schulman et al. (1986) studied this question.
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