Why the study?
Does low-molecular-weight heparin reduce progression to deep vein thrombosis in patients with isolated calf muscle vein thrombosis?
Population
84 patients with isolated calf muscle vein thrombosis (soleal and gastrocnemial muscle veins)
Comparison
Low-molecular-weight heparin for 10 days at… vs Compression therapy alone
Design
Cohort
Authors
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Therapeutic anticoagulation may reduce progression in isolated calf DVT; hypothesis-generating and should not yet change practice without RCTs.
Does low-molecular-weight heparin reduce progression to deep vein thrombosis in patients with isolated calf muscle vein thrombosis?
Short-term therapeutic low-molecular-weight heparin significantly reduces the progression of isolated calf muscle vein thrombosis to deep vein thrombosis compared to compression therapy alone.
Schwarz et al. (2001) studied this question.
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