Why the study?
Does the Pall LG-6 leucocyte-depleting arterial line filter improve postoperative complications and lung function compared to the Pall EC PLUS filter in patients undergoing routine open-heart surgery?
Does the Pall LG-6 leucocyte-depleting arterial line filter improve postoperative complications and lung function compared to the Pall EC PLUS filter in patients undergoing routine open-heart surgery?
The use of a leucocyte-depleting arterial line filter during cardiopulmonary bypass significantly reduces ventilator hours and improves immediate post-bypass oxygenation compared to a standard filter.
LG-6 filter use was associated with shorter ventilator time; hypothesis-generating finding leaves open need for randomized confirmation in cardiac surgery.
Research has demonstrated that leucocyte depletion diminishes the deleterious effects that activated neutrophils have on the body following cardiopulmonary bypass (CPB). A clinical evaluation involving 36 patients (18 in each group) was conducted to compare the use of the Pall LG-6 (leucocyte-depleting) arterial line filter with the Pall EC PLUS filter for postoperative complications and lung function on routine open-heart cases. No differences were found between the groups for postoperative chest tube drainage, urine output, on bypass platelet drop, chest X-rays, blood usage and circulating elastase levels. Statistically significant differences were observed between immediately post-CPB pO 2 values and ventilator hours (EC PLUS = 13.3, LG-6 = 9.2). Many of the advantages of using leucocyte depletion that have been illustrated through experimental investigations were comparable to our clinical observations. We conclude that using the LG-6 leucocyte-depleting arterial line filter is a cost-effective method to reduce the complications known as 'postperfusion' syndrome.
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Palanzo et al. (1993) studied this question.