Why the study?
Does titration with an initially lower dose of cilostazol reduce the incidence of headache and improve medication compliance in diabetic patients?
Does titration with an initially lower dose of cilostazol reduce the incidence of headache and improve medication compliance in diabetic patients?
Titrating cilostazol from an initially lower dose (50 mg once daily) significantly reduces the incidence and severity of headache and decreases medication discontinuation in diabetic patients compared to starting at the standard dose.
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Slow titration of cilostazol reduces discontinuation due to headache in diabetes; confirms titration improves tolerability and supports adoption in practice.
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Kim et al. (2006) studied this question.
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