Aseptic Necrosis of Bone in Myxedema

Brief Reports1 November 1977Aseptic Necrosis of Bone in MyxedemaHERBERT M. RUBINSTEIN, M.D., F.A.C.P., MARION H. BROOKS, M.D., F.A.C.P.HERBERT M. RUBINSTEIN, M.D., F.A.C.P.Search for more papers by this author, MARION H. BROOKS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-580 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGrowth retardation and delayed skeletal maturation are well-known manifestations of cretinism and juvenile myxedema. Patients with these conditions have abnormal ossification of epiphyseal centers that may appear porous, stippled, or fragmented on roentgenogram (epiphyseal dysgenesis). These changes are most pronounced in large ossification centers such as the femoral head and tarsal navicular. In the femoral head, clinical and radiographic features resemble Legg-Calvé-Perthes disease, but there are marked differences in pathology and response to thyroid hormone administration (1, 2). In the adult, thyroid hormone deficiency is associated with decreased metabolic activity and remodeling of bone (2), but overt skeletal disease has...References1. WILKINS L: Epiphyseal dysgenesis associated with hypothyroidism. Am J Dis Child 61:13-34, 1941 Google Scholar2. SOBELBRAUNWALD BE: Cardiovascular system in hypothyroidism, in The Thyroid. A Fundamental and Clinical Text, 3rd ed., edited by WERNER SC, INGBAR SH. New York, Harper and Row, 1971, pp. 727-733 Google Scholar3. DAVIDSON J (ed.): Aseptic Necrosis of Bone. Amsterdam, Exerpta Medica, 1976, pp. 3-269 Google Scholar4. ZINN W (ed.): Idiopathic Ischemic Necrosis of the Femoral Head in Adults. Baltimore, University Park Press, 1971, pp. 1-157 Google Scholar5. KÖHLERZIMMER AE: Borderlands of the Normal and Early Pathologic in Skeletal Roentgenology, 3rd American ed. based on 11th German ed. New York, Grune and Stratton, 1968 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Loyola University Stritch School of Medicine Maywood, IL 60153 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPituitary and Thyroid DisordersFreiberg’s Infraction in Identical Twins: A Case ReportBone and joint manifestations of hypothyroidismThyroïde et affections ostéo-articulaires. Associations pathologiques chez l'adulteEndocrine ArthropathiesExperimental models 1 November 1977Volume 87, Issue 5Page: 580-581KeywordsBoneBone remodelingClinical pathologyMetabolic disordersNecrosisThyroid hormones Issue Published: 1 November 1977 PDF DownloadLoading ...