Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer

Figure 1. Frequency of POSTN genetic alterations across PCa datasets analyzed by cBioPortal. Deep deletion (blue), amplification (red), and mutation (green). Full description of PCa studies included in the figure is found on https://www.cbioportal.org/.

Figure 2. Association of POSTN mRNA with DFS in the MSKCC cohort of primary PCa. (A) Kaplan-Meier estimations in patients with POSTN >1 (purple), >0-≤1 (gray), and ≤0 (light blue) z-scores; (B) X-tile histogram of POSTN values (expressed as z-scores ×10) according to number of patients; (C) triangular X-tile plot with the choice of POSTN cutoff (black point); (D) continuous relative risk of disease progression (expressed as hazard ratio) according to POSTN values (z-scores cutoffs of 0 and 1 are shown in red lines).

Figure 3. Correlation of POSTN mRNA expression (z-scores) with Gleason score (A), tumor stage (B), and nodes positivity (C) in the Firehose Legacy TCGA cohort of primary PCa.

Figure 4. POSTN mRNA expression in NT, primary PCa, and mCRPC using GSE32269, GSE101607, and GSE70768 datasets. Numbers in brackets are sample analyzed. ** P < .01.

Figure 5. STRING protein-protein interaction network of 28 mRNA enriched in patients with high POSTN mRNA expression both in primary TCGA and in metastatic SU2CF/PCF cohorts.

Figure 6. Association of POSTN protein plasma values with OS in our cohort of mCRPC patients. Curves are constructed using the Kaplan-Meier estimations. HR, hazard ratios resulting from the Cox regression models.