Key result
High periostin expression in breast cancer patients was associated with a significantly higher rate of 5-year postoperative distant metastasis compared to those without expression (53.89% vs 12.68%, OR 5.829).
Population
1,086 patients with histologically confirmed breast cancer who underwent curative radical operations, mean…
Design
Cohort
Authors
Loading...
High periostin expression may aid metastasis risk stratification in breast cancer; leaves open its value as a therapeutic target.
Cohort (n=1,086)
Yes
Odds Ratio: 5.829 (95% CI 3.582–9.485)
Absolute Event Rate: 53.89% vs 12.68%
p-value: p=0.001
High periostin expression is associated with breast cancer stem cells, chemotherapy resistance, and serves as an independent prognostic marker for poor survival and distant metastasis in breast cancer.
Xu et al. (2012) conducted a cohort in Breast cancer (n=1,086). High periostin expression vs. Low or no periostin expression was evaluated on 5-year postoperative distant metastasis (OR 5.829, 95% CI 3.582-9.485, p=0.001). High periostin expression in breast cancer patients was associated with a significantly higher rate of 5-year postoperative distant metastasis compared to those without expression (53.89% vs 12.68%, OR 5.829).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: