Key result
This is a study protocol for a systematic review and meta-analysis, and therefore contains no clinical results.
Why the study?
Although TAVI effectively treats aortic stenosis in patients of advanced age, age remains a key risk factor, prompting a comparison of outcomes between octogenarians and younger patients.
Does transcatheter aortic valve implantation (TAVI) have different clinical outcomes in octogenarian patients compared to younger patients with aortic stenosis?
Systematic Review
Does transcatheter aortic valve implantation (TAVI) have different clinical outcomes in octogenarian patients compared to younger patients with aortic stenosis?
This study protocol outlines a systematic review and meta-analysis to evaluate the clinical outcomes of TAVI in octogenarian patients compared to younger patients with aortic stenosis.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for TAVI risk stratification by age; prospective trials needed to guide octogenarian selection.
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an effective treatment to aortic stenosis in patients with advanced age. However, age is recognized as one of the most important risk factors. The aim of our study is to compare the outcome of TAVI between octogenarian patients and young patients. METHODS: Randomized controlled trials, cohort studies and propensity score matching studies will be included in our systematic review and meta-analysis to evaluate clinical outcome in octogenarian patients who undergo TAVI. PubMed, EMBASE, MEDLINE, Cochrane Library and Web of Science will be searched using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Retrieved records, extract information and assess the risk of bias will be screened by two reviewers independently. STATA software will be used to conduct data synthesis. There is no requirement of ethical approval and informed consent. RESULTS: This study will eventually be published in a peer reviewed journal in the form of a scientific paper. CONCLUSION: This study will provide a comprehensive review of the available evidence for the treatment of aortic stenosis in octogenarian patients underwent TAVI. We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. PROSPERO REGISTRATION NUMBER: CRD42020155189. STUDY PROTOCOL REGISTRY: The protocol has been registered in PROSPERO, which is an International Prospective Register of Systematic Reviews. The registration number is CRD42020155189. ETHICS AND DISSEMINATION: Ethics approval and patient consent are not required as this study is a systematic review and meta-analysis.
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Zhu et al. (2020) conducted a systematic review in Aortic stenosis. Transcatheter aortic valve implantation (TAVI) in octogenarians vs. TAVI in younger patients (<80 years) was evaluated on All-cause mortality in hospital, at 30-day, at 1-year and more than 1-year. This is a study protocol for a systematic review and meta-analysis, and therefore contains no clinical results.
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