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July 19, 2010Proceedings of the National Academy of Sciences

Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload

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Key result

Cardiac-specific overexpression of Rgs5 protected mice against pressure overload-induced cardiac hypertrophy and fibrosis by inhibiting MEK-ERK1/2 signaling.

Why the study?

Does cardiac-specific overexpression of human Rgs5 gene prevent cardiac hypertrophy and fibrosis in mice subjected to pressure overload?

Population

Transgenic mice with cardiac-specific overexpression of human Rgs5 gene and Rgs5-/- mice subjected to…

Comparison

Cardiac-specific overexpression of human Rgs5 gene vs Rgs5-/- mice (knockout model)

Design

Preclinical

Authors

HLHongliang LiCHChengwei HeJFJinhua Feng

Discussion

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Member takes

Overview

Hypothesis-generating for Rgs5 as anti-remodeling target; leaves open translation to human pressure-overload heart failure.

Structured PICO

Does cardiac-specific overexpression of human Rgs5 gene prevent cardiac hypertrophy and fibrosis in mice subjected to pressure overload?

P
Population
Transgenic mice with cardiac-specific overexpression of human Rgs5 and Rgs5-/- mice subjected to aortic banding to induce pressure overload.
I
Intervention
Cardiac-specific overexpression of human Rgs5 gene
C
Comparator
Rgs5-/- mice (knockout model)
O
Outcome
Cardiac hypertrophy and fibrosis in response to pressure overloadsurrogate

Rgs5 protects against pathological cardiac remodeling and fibrosis during pressure overload by inhibiting MEK-ERK1/2 signaling, highlighting its potential as a therapeutic target in heart failure.

Limitations

  • Preclinical animal model study; findings may not directly translate to human clinical practice.

Cite This Study

Li et al. (2010) studied Cardiac hypertrophy and fibrosis. Cardiac-specific overexpression of human Rgs5 vs. Wild-type littermates was evaluated on Cardiac hypertrophy and fibrosis. Cardiac-specific overexpression of Rgs5 protected mice against pressure overload-induced cardiac hypertrophy and fibrosis by inhibiting MEK-ERK1/2 signaling.

synapsesocial.com/papers/6a904c403dd9003d79c911ffhttps://doi.org/10.1073/pnas.1008397107
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Also Consider

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  1. 1Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase–Extracellular Signal-Regulated Protein Kinase 1/2 Signaling2015 · 47 citations
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  4. 4Regulator of G protein signaling 5 attenuates cardiac hypertrophy through modulation of Keap1/Nrf2-associated lipid peroxidation and DNA damage2026
  5. 5Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal–Regulating Kinase 1–P38/c‐JUN N‐Terminal Kinase 1/2 Signaling2018 · 23 citations