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September 25, 2018Journal of the American Heart AssociationOpen Access

Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal–Regulating Kinase 1–P38/c‐JUN N‐Terminal Kinase 1/2 Signaling

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Why the study?

Does RGS6 genetic manipulation affect cardiac hypertrophy and remodeling in response to pressure overload or angiotensin II?

Population

Failing human hearts, hypertrophic murine hearts, cardiac-specific RGS6 knockout mice, transgenic mice with…

Comparison

Genetic manipulation of RGS6 and exposure to… vs Control/wild-type mice and cardiomyocytes

Design

Preclinical

Authors

ZHZhijun HuangJSJingxian ShuWJWeihong Jiang

Discussion

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Overview

RGS6-ASK1 merits target validation in pressure-overload remodeling; animal findings leave human translation open.

Structured PICO

Does RGS6 genetic manipulation affect cardiac hypertrophy and remodeling in response to pressure overload or angiotensin II?

P
Population
Failing human hearts, hypertrophic murine hearts, cardiac-specific RGS6 knockout mice, transgenic mice with cardiac-specific RGS6 overexpression, and isolated cardiomyocytes
I
Intervention
Genetic manipulation of RGS6 (knockout or overexpression) and exposure to angiotensin II or pressure overload (aortic banding)
C
Comparator
Control/wild-type mice and cardiomyocytes
O
Outcome
Extent of cardiac hypertrophy, dysfunction, and fibrosissurrogate

RGS6 aggravates cardiac hypertrophy by interacting with apoptosis signal-regulating kinase 1, suggesting the RGS6-ASK1 pathway as a potential therapeutic target for pressure overload-driven cardiac remodeling.

Cite This Study

Huang et al. (2018) studied this question.

synapsesocial.com/papers/6a82903c8aa2f088808d5b06https://doi.org/10.1161/jaha.118.009179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy2016 · 32 citations
  2. 2Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase–Extracellular Signal-Regulated Protein Kinase 1/2 Signaling2015 · 47 citations
  3. 3Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload2010 · 149 citations
  4. 4Regulator of G Protein Signaling Protein 6 (RGS6) Protects the Heart from Ischemic Injury2015
  5. 5Deregulation of RGS2 in cardiovascular diseases2009 · 43 citations