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April 16, 2011AJP Heart and Circulatory PhysiologyOpen Access

Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses

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Why the study?

Does RGS2 regulate Angiotensin II-induced signaling and function in ventricular fibroblasts?

Population

In vitro model of ventricular fibroblast activation and fibroblasts isolated from rat hearts

Comparison

Angiotensin II stimulation and RGS2… vs Unstimulated/control fibroblasts

Design

Preclinical

Follow-up

1 to 14 days (in vivo)

Authors

PZPeng ZhangHebei Medical UniversityJSJialin SuSun Yat-sen UniversityMKMichelle E. KingBrown University

Discussion

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Implication

May indicate RGS2 protects against ANG II-driven cardiac fibrosis in rodents; leaves open therapeutic targeting in human disease.

Structured PICO

Does RGS2 regulate Angiotensin II-induced signaling and function in ventricular fibroblasts?

P
Population
In vitro model of ventricular fibroblast activation and fibroblasts isolated from rat hearts
I
Intervention
Angiotensin II stimulation (in vitro and in vivo via minipumps) and RGS2 gain/loss-of-function (adenoviral infection / RNA interference)
C
Comparator
Unstimulated/control fibroblasts
O
Outcome
RGS2 expression levels, phospholipase Cβ activity, cell proliferation, and total collagen productionsurrogate

RGS2 acts as a functionally important negative regulator of Angiotensin II-induced cardiac fibroblast responses, suggesting a protective role against fibrosis development.

Cite This Study

Zhang et al. (2011) studied this question.

synapsesocial.com/papers/6a87ea05f8efd6d7e4fb204chttps://doi.org/10.1152/ajpheart.00026.2011
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Also Consider

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  1. 1Administration of Granulocyte Colony-Stimulating Factor After Myocardial Infarction Enhances the Recruitment of Hematopoietic Stem Cell-Derived Myofibroblasts and Contributes to Cardiac Repair2007 · 82 citations
  2. 2Deregulation of RGS2 in cardiovascular diseases2009 · 43 citations
  3. 3Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice2003 · 335 citations
  4. 4Renin–angiotensin–aldosterone system and myocardial fibrosis2000 · 132 citations
  5. 5RGS4 and GAIP are GTPase-activating proteins for G qα and block activation of phospholipase Cβ by γ-thio-GTP-G qα1997 · 365 citations