Key result
Angiotensin II induces RGS2 mRNA up-regulation in vascular smooth muscle cells via a cAMP-response element in the RGS2 promoter, delineating a negative feedback loop to attenuate Ang II signaling.
Population
Cultured vascular smooth muscle cells (VSMCs) and murine/human RGS2 promoter models
Comparison
Angiotensin II stimulation, forskolin, and… vs Control conditions
Design
Preclinical
Authors
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May link RGS2 variants to hypertension via impaired feedback; leaves open therapeutic targeting in humans.
Identifies a critical CREB-binding site in the RGS2 promoter required for Ang II-induced negative feedback in vascular smooth muscle cells, which is impaired by genetic variants linked to human hypertension.
Xie et al. (2011) studied Hypertension. Angiotensin II was evaluated on RGS2 mRNA up-regulation and promoter activation. Angiotensin II induces RGS2 mRNA up-regulation in vascular smooth muscle cells via a cAMP-response element in the RGS2 promoter, delineating a negative feedback loop to attenuate Ang II signaling.
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