Key result
Primary Sjögren syndrome was not associated with significant differences in carotid intima-media thickness, stiffness, or haemodynamic parameters compared to matched controls.
Why the study?
Does primary Sjögren syndrome increase subclinical carotid atherosclerosis compared to matched controls in an elderly population?
Case-Control (n=36)
No
Does primary Sjögren syndrome increase subclinical carotid atherosclerosis compared to matched controls in an elderly population?
In elderly patients, primary Sjögren syndrome with a median disease duration of 6.5 years does not appear to accelerate subclinical carotid atherosclerosis compared to matched controls.
Primary Sjögren syndrome does not increase subclinical carotid atherosclerosis in the elderly; leaves open effects in longer-duration disease or other vascular beds.
A growing body of evidence presents a link between chronic inflammatory rheumatic diseases and atherosclerosis. To evaluate subclinical carotid atherosclerosis in an elderly group of patients with primary Sjögren syndrome compared with a control group matched for age, sex, ethnicity and cardiovascular risk factors, we enrolled 18 patients with Primary Sjögren Syndrome (mean age 65 ± 5.93 SD) and 18 mild Ostheoarthritic patients (mean age 66 ± 5.94 SD) from the outpatient department of Rheumatology, University Campus Bio-Medico, Rome, Italy, matched for age, sex, ethnicity and cardiovascular risk factors. A duplex Doppler sonographic study of carotids was performed in order to evaluate intima-media thickness (IMT), stiffness and haemodynamic parameters [resistivity and pulsatility indices (RI and PI, respectively)]. No significant difference was found between primary Sjögren syndrome and control patients in IMT, stiffness and haemodynamic parameters. The lack of significant difference in subclinical atherosclerosis between elderly primary Sjögren syndrome and control matched patients, indicates that traditional cardiovascular risk factors, immunologic alterations and chronic inflammation do not influence the progression of vascular damage in the carotid circulation of patients with median disease duration of 6.5 years.
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Zardi et al. (2014) conducted a case-control in Primary Sjögren Syndrome (n=36). Primary Sjögren Syndrome vs. Mild osteoarthritic patients was evaluated on Intima-media thickness (IMT), stiffness and haemodynamic parameters. Primary Sjögren syndrome was not associated with significant differences in carotid intima-media thickness, stiffness, or haemodynamic parameters compared to matched controls.
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