Key result
Physical exercise significantly reduces inflammatory chemokines MCP-1 and IL-8 in metabolic syndrome.
Why the study?
Inflammation and chemokines MCP-1 and IL-8 play a pivotal role in atherosclerosis and may link type 2 diabetes, metabolic syndrome, and atherosclerosis, but the effect of exercise on these inflammatory markers in metabolic syndrome is unclear.
Does physical exercise reduce peripheral markers of inflammation in subjects with the metabolic syndrome?
RCT
Open-label
2x2 factorial
Does physical exercise reduce peripheral markers of inflammation in subjects with the metabolic syndrome?
Effect estimate: Reduction of 48 pg/ml (MCP-1) and 1.0 pg/ml (IL-8)
p-value: P=0.04 (MCP-1) and P=0.007 (IL-8)
Physical exercise significantly reduces plasma levels of the inflammatory chemokines MCP-1 and IL-8 in subjects with metabolic syndrome, suggesting a mechanism for its protective cardiovascular effects.
Supports exercise to lower inflammation in metabolic syndrome; extends evidence for its anti-inflammatory cardiovascular mechanisms.
AIMS: Inflammation plays an essential role in the atherosclerotic process, and chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) seem to play a pivotal role in the pathogenesis of atherosclerosis. A possible common inflammatory basis for the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis has been suggested. In this study we investigated the effect of physical exercise and the HMG-CoA reductase inhibitor pravastatin on peripheral markers of inflammation in subjects with the metabolic syndrome. METHODS: The study was an unmasked randomized 2x2 factorial trial of 12 weeks duration. RESULTS: In the combined exercise groups there was a significant reduction in MCP-1 and IL-8 of 48 pg/ml (P=0.04) and 1.0 pg/ml (P=0.007), respectively, as compared to the combined non-exercise groups. There was also a significant reduction vs baseline of 50 pg/ml (33%) (P=0.002) and 0.35 pg/ml (13%) (P=0.03) for MCP-1 and IL-8, respectively. Changes in MCP-1 were significantly correlated to changes in visceral fat (r=0.41, P=0.02). CONCLUSION: The protective effect of exercise might in part be due to suppression of the inflammatory process.
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Marius Trøseid (2004) conducted an RCT in Metabolic syndrome. Physical exercise vs. Non-exercise was evaluated on Plasma levels of MCP-1 and IL-8 (Reduction of 48 pg/ml (MCP-1) and 1.0 pg/ml (IL-8), p=P=0.04 (MCP-1) and P=0.007 (IL-8)). Physical exercise significantly reduced plasma levels of MCP-1 by 48 pg/ml (P=0.04) and IL-8 by 1.0 pg/ml (P=0.007) compared to non-exercise in subjects with metabolic syndrome.
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