This review highlights that labile blood components have a limited role in reversing most anticoagulants and are often used inappropriately.
May reduce unnecessary transfusions if requests are curtailed; leaves open optimal reversal strategies for specific agents.
Increasing use of anticoagulants especially in an elderly population may complicate management of trauma, surgery and spontaneous bleeds. Reversal of warfarin and standard heparin are both effective and relatively easy. Newer agents are associated with fewer spontaneous bleeds but reversal when necessary may be difficult. Use of labile blood components has a very limited role in active reversal of anticoagulation for most agents but are often requested, usually inappropriately. This brief review looks at the options available for older and some newer agents.
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J. P. Wallis (2012) studied this question.
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