Key result
A systolic blood pressure of < 100 mmHg during dialysis was independently associated with higher odds of reporting more intra-dialytic symptoms (OR 2.53).
Why the study?
Haemodialysis patients may experience symptoms during dialysis and prolonged recovery, but whether symptomatic intra-dialytic hypotension requiring intervention versus asymptomatic falls in systolic blood pressure relates to symptom reporting was unclear.
Does a fall in systolic blood pressure during haemodialysis increase intra-dialytic symptoms and prolong post-dialysis recovery times in haemodialysis patients?
Observational (n=603)
Yes
Does a fall in systolic blood pressure during haemodialysis increase intra-dialytic symptoms and prolong post-dialysis recovery times in haemodialysis patients?
Odds Ratio: 2.53 (95% CI 1.04–6.14)
p-value: p=0.040
Asymptomatic falls in systolic blood pressure during haemodialysis are associated with increased patient self-reported symptoms and prolonged recovery times, suggesting a need to minimize intra-dialytic blood pressure changes.
Symptomatic IDH may drive more intra-dialytic symptoms than asymptomatic SBP falls; leaves open whether interventions should target BP thresholds alone.
Background Haemodialysis (HD) patients may suffer symptoms during dialysis and take time to recover post HD. We wished to determine whether patients with symptomatic intra-dialytic hypotension (IDH), requiring nursing interventions, or an asymptomatic fall in systolic blood pressure (SBP) reported more symptoms during dialysis. Methods Six hundred three HD patients completed self-reported intra-dialytic symptom questionnaires and recovery using a visual analogue scale, which were compared with their dialysis session records. Results Twenty-nine (4.8%) of patients suffered symptomatic IDH, and 187 (31.0%) had a fall in SBP of > 20 mmHg. Symptomatic patients had greater total symptom scores (30 (23–44) vs 23 (10–38), p < 0.05, versus asymptomatic patients, with increased low blood pressure, dizziness, cramps, palpitations and feeling cold reported (all p < 0.05). Patients with a SBP fall of > 20 mmHg had greater total scores compared with those with a SBP increase of > 10 mmHg (26 (13–38) vs 17 (7–34), p < 0.05), with more dizziness, cramps, backache, shortness of breath and headache reported (all p < 0.05). Although ultrafiltration rates were similar, HD weight loss was greater for patients with a SBP fall of > 20 mmHg (2.5 ± 1.1 vs 2.0 ± 1.3%, p < 0.05). Patients with highest symptoms scores (highest vs lowest quartile) had longer recovery times (40.3 vs 7.6% > 4 h), p < 0.001. Multivariable analysis showed that patients reporting more intradialytic symptoms had higher psychological distress thermometer scores (odds ratio (OR) 1.34 (95% confidence limits 1.26–1.44)), systolic blood pressure < 100 mmHg (OR 2.53 (1.04–6.1)), whereas symptom scores were lower for male gender (OR 0.34 (0.22–0.51)), and with increasing age (OR 0.99 (0.97–0.99)). Conclusion Patients with both symptomatic and asymptomatic IDH, self-reported more symptoms during dialysis, and those patients reporting more symptoms had longer recovery times. We found that younger, female patients, those with greater psychological distress, and lower systolic blood pressure self-reported more intra-dialytic symptoms. More attention is required to prevent falls in intra-dialytic blood pressure to improve the patient experience of HD and shorten post-dialysis recovery times.
No takes yet. Share an insight, caveat, or question.
Yoowannakul et al. (2020) conducted an observational in End-stage renal disease on haemodialysis (n=603). Systolic blood pressure < 100 mmHg during dialysis vs. Systolic blood pressure ≥ 100 mmHg was evaluated on High self-reported total dialysis symptom score (OR 2.53, 95% CI 1.04-6.14, p=0.040). A systolic blood pressure of < 100 mmHg during dialysis was independently associated with higher odds of reporting more intra-dialytic symptoms (OR 2.53).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: