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Experimental study demonstrates that surface contact activates plasma clotting specifically via Hageman factor, suggesting asbestos treatment as a diagnostic test for Hageman trait.
Asbestos treatment of plasma produced activation (clotting-time acceleration) in normal and AHF, PTC, proconvertin, prothrombin, proaccelerin and Stuart deficient plasmas. Hageman deficient plasma was not activated by comparable treatment. 2. Purified Hageman factor preparations from normal sera simulated activation, whereas preparations from sera of Hageman trait patients were inactive in the same test system. 3. The phenomenon of surface activation resulted from Hageman factor activation and was not due to inhibitor adsorption. 4. Asbestos treatment of plasma may be used as a presumptive test for Hageman trait.
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Johnston et al. (1958) studied this question.
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