What question did this study set out to answer?

To determine how high molecular weight kininogen and prekallikrein influence the surface-dependent activation and enzymatic function of human Hageman factor.

July 1, 1977Journal of Clinical InvestigationOpen Access

Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein.

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To determine how high molecular weight kininogen and prekallikrein influence the surface-dependent activation and enzymatic function of human Hageman factor.
Assessed surface-bound Hageman factor activity toward prekallikrein and Factor XI in the presence and absence of high molecular weight kininogen in human plasma.
Analyzed the reciprocal enzymatic activation dynamics between Hageman factor and kallikrein, including the stoichiometric effects of high molecular weight kininogen.
High molecular weight kininogen does not alter Hageman factor binding to surfaces, but it enhances surface-bound Hageman factor activity to convert prekallikrein and Factor XI.
Kallikrein drives rapid activation of Hageman factor through an enzymatic positive feedback loop facilitated by high molecular weight kininogen, producing most of the activated factor during surface exposure.
Prekallikrein and high molecular weight kininogen assemble as a complex that optimizes contact with Hageman factor, while the surface acts passively to support their assembly.

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Implication

In vitro study reveals reciprocal activation between Hageman factor and prekallikrein mediated by high molecular weight kininogen in human plasma, highlighting a positive feedback clotting loop.

Cite This Study

Meier et al. (1977) studied this question.

synapsesocial.com/papers/6a716b6a31a3df8243299bc6 https://doi.org/10.1172/jci108754

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Implication

In vitro study reveals reciprocal activation between Hageman factor and prekallikrein mediated by high molecular weight kininogen in human plasma, highlighting a positive feedback clotting loop.

Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein.

Key Points

Discussion

Implication

Cite This Study

Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein.

Key Points

Discussion

Implication

Cite This Study

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