Population
In vitro plasma samples including acid-treated plasma, plasminogen-free plasma, Hageman factor-deficient…
Design
Preclinical
Authors
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Biochemical link between coagulation-kinin and renin-angiotensin systems shown in vitro; leaves open in vivo relevance and clinical translation.
Demonstrates a biochemical link between the coagulation-kinin pathway and the renin-angiotensin system via Hageman factor-dependent activation of prorenin.
Sealey et al. (1979) studied this question.
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