September 29, 2014BiochemistryOpen Access

Modulation of Thin Filament Activation of Myosin ATP Hydrolysis by N-Terminal Domains of Cardiac Myosin Binding Protein-C

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Structured PICO

Population

Human and mouse cardiac MyBP-C (C0C1, C1C2, and C0C2) and native porcine thin filaments

Intervention

N-terminal domains of cMyBP-C (C0C1, C1C2, C0C2) at varying concentrations

Comparator

F-actin alone or different concentrations/ratios

Outcome

Activation of myosin ATP hydrolysis (myosin-S1 ATPase rate)surrogate

In sarcomeres, the low ratio of cMyBP-C to actin likely favors activating effects while minimizing inhibition from competition with myosin heads.

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May fine-tune sarcomere contractility via cMyBP-C ratios; hypothesis-generating for mechanisms in cardiomyopathy.

Belknap et al. (2014) studied this question.

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