July 1, 1988Journal of Biological ChemistryOpen Access

Regulation of alternatively spliced alpha-tropomyosin gene expression by nerve extract.

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Population

Muscle cells, non-muscle cells, and primary muscle cells

Design

Preclinical

Authors

DWDavid F. WieczorekDivision of Molecular & Cellular Biosciences

Discussion

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Implication

Neural regulation of tropomyosin splicing in animal extracts does not inform clinical practice; leaves open relevance to human cardiac isoform switching.

Structured PICO

Population

Muscle cells, non-muscle cells, and primary muscle cells

Intervention

Incubation with extracts prepared from neural tissue

Outcome

Alteration of alpha-TM transcripts (decreasing striated specific isoform and increasing cytoplasmic isoform)surrogate

Neural factors regulate alpha-tropomyosin expression at the post-transcriptional level by altering exon splice site selection, a mechanism common across different cell types.

Cite This Study

David F. Wieczorek (1988) studied this question.

synapsesocial.com/papers/6a905796039ece43b30d46ef https://doi.org/10.1016/s0021-9258(19)81538-7

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Implication

Neural regulation of tropomyosin splicing in animal extracts does not inform clinical practice; leaves open relevance to human cardiac isoform switching.

Regulation of alternatively spliced alpha-tropomyosin gene expression by nerve extract.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of alternatively spliced alpha-tropomyosin gene expression by nerve extract.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider