April 1, 1987Journal of Biological ChemistryOpen Access

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

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Population

Cloned complementary DNAs (cDNAs) for striated and smooth muscle alpha-tropomyosin

Design

Preclinical

Authors

NRNelson Ruiz‐OpazoBoston University BNB Nadal-GinardKing's College London

Discussion

Member takes

Implication

No immediate clinical implications; leaves open tropomyosin splicing relevance to human cardiac disease.

Structured PICO

Population

Cloned complementary DNAs (cDNAs) for striated and smooth muscle alpha-tropomyosin

Intervention

Gene structure analysis and sequence comparison

Outcome

Complete structure of the alpha-tropomyosin (alpha-TM) gene and alternative splicing mechanisms

The study elucidates the genomic organization of alpha-tropomyosin, demonstrating that alternative splicing of a single gene generates distinct smooth and striated muscle isoforms.

Cite This Study

Ruiz‐Opazo et al. (1987) studied this question.

synapsesocial.com/papers/6a23f5e79e1c90a91c097b80 https://doi.org/10.1016/s0021-9258(18)61260-8

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Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider