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February 1, 1988Molecular and Cellular BiologyOpen Access

The Rat α-Tropomyosin Gene Generates a Minimum of Six Different mRNAs Coding for Striated, Smooth, and Nonmuscle Isoforms by Alternative Splicing

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Population

Rat alpha-tropomyosin gene and cells (preclinical model)

Design

Preclinical

Authors

DWDavid F. WieczorekDivision of Molecular & Cellular BiosciencesCSChristopher W. J. SmithUniversity of LeedsBNBernardo Nadal‐GinardHeart Failure / Cardiomyopathy

Discussion

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Implication

Highlights alternative splicing in contractile genes; leaves open human cardiac isoform relevance.

Structured PICO

P
Population
Rat alpha-tropomyosin gene and cells (preclinical model)
I
Intervention
Molecular biology analyses (S1 nuclease mapping, RNA blots, 5' extension analyses)
O
Outcome
Gene structure and mRNA isoform generation

The rat alpha-tropomyosin gene generates at least six different tissue-specific mRNA isoforms through alternative splicing, challenging the assumption that different isoforms are encoded by different sets of genes.

Cite This Study

Wieczorek et al. (1988) studied this question.

synapsesocial.com/papers/6a70171fe36a167817e1d17dhttps://doi.org/10.1128/mcb.8.2.679-694.1988
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation and sequence of a cDNA clone that contains the entire coding region for chicken smooth-muscle alpha-tropomyosin.1984 · 57 citations
  2. 2Amino acid sequence of chicken gizzard beta-tropomyosin. Comparison of the chicken gizzard, rabbit skeletal, and equine platelet tropomyosins.1985 · 70 citations
  3. 3Low Mr tropomyosin isoforms from chicken brain and intestinal epithelium have distinct actin-binding properties.1986 · 73 citations
  4. 4Polymorphism of myofibrillar proteins of rabbit skeletal-muscle fibres. An electrophoretic study of single fibres1982 · 119 citations
  5. 5DNA sequencing with chain-terminating inhibitors1977 · 69,512 citations