Key result
The rat brain generates at least 10 mRNA tropomyosin isoforms with extensive developmental regulation and differential localization, suggesting a role in developing specific neuronal compartments.
Population
Cultured primary cortical neurons and rat brain
Design
Preclinical
Authors
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Animal data on rat tropomyosin isoforms do not guide therapy; leaves open roles in human neurodevelopment.
Tropomyosin isoforms exhibit tightly regulated spatial and temporal expression in the rat brain, suggesting an important role in neuronal development and maintenance.
Dufour et al. (1998) studied Neuronal morphogenesis. Tropomyosin isoforms was evaluated on Tropomyosin isoform diversity and localization. The rat brain generates at least 10 mRNA tropomyosin isoforms with extensive developmental regulation and differential localization, suggesting a role in developing specific neuronal compartments.
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