December 11, 2003FEBS LettersOpen Access

Myofibrillar tightly bound calcium in skeletal muscle fibers: a possible role of this cation in titin strands aggregation

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Population

Recombinant titin fragment spanning titin domains Z9 to I1 (skeletal muscle fibers model)

Design

Preclinical

Authors

GCGérald CoulisUniversity of California, Irvine MSMiguel Ángel SentandreuInstituto de Agroquímica y Tecnología de Alimentos NBNathalie BleimlingMax Planck Institute of Molecular Physiology

Discussion

Member takes

Implication

Hypothesis-generating for titin filament organization; leaves open relevance to human sarcomere function or cardiomyopathy.

Structured PICO

Population

Recombinant titin fragment spanning titin domains Z9 to I1 (skeletal muscle fibers model)

Intervention

Calcium ions

Outcome

Calcium binding affinity (Kd) and spontaneous aggregation of the titin fragmentsurrogate

Calcium tightly binds to specific titin domains, inducing tetramer aggregation, which may explain the organization of titin strands in the sarcomere I-band.

Cite This Study

Coulis et al. (2003) studied this question.

synapsesocial.com/papers/6a9057fd7b6e700e2c8a4f36 https://doi.org/10.1016/s0014-5793(03)01436-4

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Myofibrillar tightly bound calcium in skeletal muscle fibers: a possible role of this cation in titin strands aggregation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myofibrillar tightly bound calcium in skeletal muscle fibers: a possible role of this cation in titin strands aggregation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider