Why the study?
Do recombinant adenoviruses expressing the BVDV/E2 protein induce humoral and cellular immune responses in a mouse model?
Do recombinant adenoviruses expressing the BVDV/E2 protein induce humoral and cellular immune responses in a mouse model?
Recombinant adenoviruses expressing the BVDV E2 protein successfully induce strong humoral and cellular immune responses in mice, highlighting their potential as a BVDV vaccine candidate.
Supports adenoviral BVDV vaccine exploration in mice; hypothesis-generating and requires bovine validation before any practice consideration.
The E2 protein of bovine viral diarrhea virus (BVDV) is a major viral glycoprotein and an attractive target for BVDV vaccines. Three replication defective recombinant adenoviruses expressing the BVDV/E2 protein (rAds/E2) were constructed. Two contain a constitutive promoter, and one an inducible promoter. All three recombinant adenoviruses induced very strong BVDV specific antibody responses in a mouse model as detected by enzyme-linked immunosorbant assay (ELISA) and neutralization tests. Induction of cellular immune responses was investigated in two recombinant adenoviruses with a constitutive promoter. The mononuclear cells from the immunized mice demonstrated a proliferative response after in vitro stimulation with an homologous BVDV strain, but only one of them induced the production of IFN-gamma.
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Elahi et al. (1999) studied this question.
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