Why the study?
Does incubation with heavy meromyosin augment tension development in glycerinated fibers of rabbit psoas muscle?
Does incubation with heavy meromyosin augment tension development in glycerinated fibers of rabbit psoas muscle?
The study supports the sliding filament theory by demonstrating that heavy meromyosin suppresses rather than augments contraction in rabbit psoas muscle fibers, highlighting the necessity of bipolar myosin filaments.
No clinical implications yet; leaves open bipolar myosin filament requirements in human cardiac muscle.
Glycerinated fibers of rabbit psoas muscle showed no augmentation of tension development upon incubation with heavy meromyosin, irrespective of whether the fibers were of standard length, stretched, or extracted of their myosin content. The effect of heavy meromyosin was to suppress contraction. These observations are in disagreement with certain recent published reports (Oplatka et al., 1974) and do tend to support the current sliding filament theory of muscle contraction and the necessity of bipolar myosin filaments for contraction. A possible mechanism of contraction in protein systems, including tension generation in actomyosin fibers and superprecipitation, is described emphasizing the polarity of both myosin and actin filaments.
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HAYASHI et al. (1975) studied this question.
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