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Enantiopure indoline-3-carboxylic acid is synthesized using an enzymatic kinetic resolution as a key step (E≫100). It is applied as an organocatalyst in Mannich-type reactions, which proceed with high anti selectivity at low temperatures, affording the products in moderate to good yields and in excellent enantiomeric excess.
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Pietruszka et al. (2010) studied this question.
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