Nutritive Adequacy and Clinical Tolerance of Modified Human Globin 1

The production of plasma and its fractions from whole blood has led to investigations of the use- fulness of the red cell residues. Globin, the protein moiety of hemoglobin, can be obtained in quantity from the red blood cells remaining after the plasma has been removed. Modification 8 (1) of this protein renders it suitable for intravenous use. Previous studies suggest that this material may have osmotic properties useful in treating shock and may be a source of protein for parenteral administration (2-7). The present investigation was designed to elucidate further the usefulness of modified human globin with particular regard to its nutritive value and clinical tolerance in man.