Highlights the essential role of unconventional myosins in neurosensory function based on genetic evidence.
May guide genetic testing in select neurosensory disorders; leaves open therapeutic targeting pending validation studies.
Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, retina and the sensory cells of the inner ear.
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Hasson et al. (1997) studied this question.
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