Population
Mice with tissue-specific knockout of Prkar1a in pituitary cells
Comparison
Pituitary-specific knockout of the Carney… vs Wild-type or conventional Prkar1a(+/-) mice
Design
Preclinical
Authors
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Validates pituitary Prkar1a loss as sufficient for GH-secreting tumors in mice; leaves open translation to Carney complex therapies.
Complete loss of Prkar1a in the pituitary is sufficient to cause pituitary tumors and GH axis abnormalities, successfully modeling human Carney complex.
Yin et al. (2007) studied this question.
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