What question did this study set out to answer?

To delineate the metabolic mechanisms underlying blood lactate accumulation and evaluate its utility as a prognostic biomarker in sepsis.

January 1, 2016Infection and ChemotherapyOpen Access

Lactate as a Biomarker for Sepsis Prognosis?

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To delineate the metabolic mechanisms underlying blood lactate accumulation and evaluate its utility as a prognostic biomarker in sepsis.
Synthesized physiological pathways regulating lactate generation, including glycolysis, pyruvate dehydrogenase inhibition, and hypoxia-driven lactate dehydrogenase activity.
Assessed hepatic clearance mechanisms and non-hypoxic contributors to elevated serum lactate, such as malignancy and liver dysfunction.
Sepsis induces hyperlactatemia through accelerated glycolysis and cellular hypoxia, which shifts metabolism toward anaerobic conversion of pyruvate to lactate by lactate dehydrogenase.
Hepatic clearance, normally responsible for removing 70% of circulating lactate, declines markedly when liver blood flow decreases to 25% of normal, exacerbating lactate accumulation.
Lactate elevations frequently stem from non-hypoperfusion causes such as hepatic disease, malignancy, or mitochondrial disorders, limiting the specificity of lactate as an isolated marker of hypoperfusion.

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Implication

Review reveals mechanisms driving elevated blood lactate during sepsis, indicating that concurrent overproduction and reduced clearance govern biomarker levels.

Cite This Study

Kang et al. (2016) studied this question.

synapsesocial.com/papers/6a905e9873c1f5e62dc92d5b https://doi.org/10.3947/ic.2016.48.3.252

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Implication

Review reveals mechanisms driving elevated blood lactate during sepsis, indicating that concurrent overproduction and reduced clearance govern biomarker levels.

Lactate as a Biomarker for Sepsis Prognosis?

Key Points

Discussion

Implication

Cite This Study

Lactate as a Biomarker for Sepsis Prognosis?

Key Points

Discussion

Implication

Cite This Study

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