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A chemoselective biocatalytic procedure for the synthesis of (4 R,6 S )-4-( tert -butyldimethylsilyloxy)-6-(hydroxymethyl)tetrahydro-2 H -pyran-2-one, a key lactonized statin side chain intermediate, from its acetate precursor is described. The presented method is based on the pancreatin powder-catalyzed cleavage of the acetyl group in ((2 S,4 R )-4-( tert -butyldimethylsilyloxy)-6-oxotetrahydro-2 H -pyran-2-yl)methyl acetate. The reaction was conducted in aqueous medium. The overall process is performed in a convenient way and economical manner suitable for industrial use.
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Troiani et al. (2011) studied this question.
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