October 1, 2011Hormone and Metabolic Research
Impaired Red Blood Cell Deformability in Patients with Coronary Artery Disease and Diabetes Mellitus
Why the study?
Does type 2 diabetes mellitus impair red blood cell deformability in patients with coronary artery disease?
Population
45 patients with coronary artery disease, comprising 21 patients with type 2 diabetes mellitus and 24…
Comparison
Presence of type 2 diabetes mellitus vs Absence of diabetes mellitus (CAD - DM group)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May worsen microvascular perfusion in diabetic CAD; leaves open whether glycemic control or targeted therapies restore deformability.
Structured PICO
Does type 2 diabetes mellitus impair red blood cell deformability in patients with coronary artery disease?
P
Population
45 patients with coronary artery disease (CAD), comprising 21 patients with type 2 diabetes mellitus (CAD + DM) and 24 patients without diabetes (CAD - DM).
I
Intervention
Presence of type 2 diabetes mellitus (observational exposure)
C
Comparator
Absence of diabetes mellitus (CAD - DM group)
O
Outcome
Red blood cell (RBC) deformability measured by elongation index (EI) using a Laser-assisted optical rotational cell analyzersurrogate
In patients with coronary artery disease, concomitant type 2 diabetes mellitus impairs red blood cell deformability, which is independently predicted by plasma glucose concentrations.
Cite This Study
Keymel et al. (2011) studied this question.