Why the study?
Venous thromboembolism due to protein S deficiency poses a significant diagnostic challenge because it often presents with atypical complaints.
Protein S deficiency should be considered in young adults presenting with atypical chest pain and pulmonary embolism, as prompt anticoagulation leads to favorable outcomes.
Supports including PE in differentials for atypical symptoms with right heart strain on echo in protein S deficiency; leaves open validation in prospective cohorts.
Venous thromboembolism has many risk factors including protein S deficiency, which poses a significant diagnostic challenge as it presents with atypical complaints. A treatable yet potentially fatal condition, acute pulmonary embolism, is currently third most common cause of cardiovascular death. Clinicians should include pulmonary embolism as differential diagnosis in young adults with atypical symptoms with 2 D ECHO findings of the dilated right atrium, right ventricle, and elevated pulmonary artery pressure, and diagnosis is confirmed by computed tomography pulmonary angiography (CTPA). Anticoagulants including NOACs should be initiated promptly to improve the outcome for patients.
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Puri et al. (2022) studied this question.
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