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December 15, 2014Australian & New Zealand Journal of Psychiatry

19% of the population were dispensed at least one antidepressant; current use was strongly associated with severe physical impairment (aRRR 3.86, 95% CI 3.67-4.06), fair/poor self-rated health (aRRR 4.04, 95% CI 3.83-4.25), high psychological distress (aRRR 7.22, 95% CI 6.81-7.66), and ever-diagnosis of depression (aRRR 18.85, 95% CI 17.95-19.79).

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Why the study?

What factors are associated with antidepressant use in mid-age and older Australians?

Population

111,705 concession card holders aged ⩾45 years from the 45 and Up Study in New South Wales, Australia

Comparison

Antidepressant use vs Non-users of antidepressants

Design

Cross-sectional

Authors

EPEllie PaigeRKRosemary KordaAKAnna Kemp

Discussion

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Overview

Antidepressant use signals complex health burdens in older Australians; cross-sectional data leave causal directions and practice implications open.

Structured PICO

What factors are associated with antidepressant use in mid-age and older Australians?

P
Population
111,705 concession card holders aged ⩾45 years from the 45 and Up Study in New South Wales, Australia
I
Intervention
Antidepressant use (current and any, including SSRIs and TCAs)
C
Comparator
Non-users of antidepressants (no antidepressants dispensed ⩽19 months before baseline)
O
Outcome
Factors associated with antidepressant use (sociodemographic, lifestyle, physical and mental health-related factors)

Antidepressant use is highly prevalent among older Australians and is strongly associated with physical ill-health, adverse mental health measures, and sociodemographic factors.

Cite This Study

Paige et al. (2014) studied this question.

synapsesocial.com/papers/6a9064f799ba4bd4fe89c972https://doi.org/10.1177/0004867414560653
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antidepressant use and depressive symptomatology among older people from the Australian Longitudinal Study of Ageing2010 · 32 citations
  2. 2Utilization patterns of antidepressants between 1991 and 2011 in a population-based cohort of middle-aged and elderly2014 · 32 citations
  3. 3Prevalence of Antidepressant Use Among Older People: Population‐Based Observations1999 · 23 citations
  4. 4A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database2011 · 150 citations
  5. 5Patterns of antidepressant use among older adults in Northern Ireland: An administrative data study.2024