Disseminated Coccidioidomycosis Associated with Immunosuppressive Therapy Following Renal Transplantation

Renal homograft transplantation has become an accepted and relatively common therapeutic approach in chronic renal failure.1 This report is concerned with the development of disseminated coccidioidomycosis in a child receiving immunosuppressive therapy following renal homograft transplantation. It would appear that a subclinical, quiescent infection was activated by the administration of immunosuppressive agents. Case Report P.M., a Caucasian male, age 10 years at the time of his death, was first seen at the Children's Hospital of Pittsburgh at 6 years of age with evidence of advanced renal disease. A diagnosis of "chronic nephritis" had been made at age 2 years. Although a native of Pennsylvania, the child had resided in Phoenix, Arizona from his second through fifth year of life.