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Agelenin isolated from the venom of the spider Agelena opu/enta, blocks neurotransmission at lobster neuromuscular synapses in an irreversible manner. The complete primary structure of agelenin, consisting of a single polypeptide chain of 35 amino acid residues, has been determined. The sequence appears to have no precedent among other known neurotoxins.
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Hagiwara et al. (1990) studied this question.
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