Why the study?
Heart valve developmental alterations comprise over 20% of congenital cardiovascular malformations, but little is known regarding extracellular matrix fibrillar components during developmental stages.
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Population
Mus musculus in late embryonic development
Design
Histological study
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Does not inform clinical management of congenital valve defects; extends basic ECM histology in murine development.
Falla-Zúñiga et al. (2020) studied this question.
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