Why the study?
Is circulating endotoxin detectable in children with hemolytic-uremic syndrome?
Population
16 children with hemolytic-uremic syndrome
Comparison
Endotoxin determination using the Limulus test vs Patients with septicemia due to gram-negative…
Design
Cross-sectional
Authors
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No detectable endotoxin in pediatric HUS plasma; hypothesis-generating against endotoxemia pathogenesis, needs prospective validation.
Is circulating endotoxin detectable in children with hemolytic-uremic syndrome?
Circulating endotoxin was not detected in children with hemolytic-uremic syndrome, challenging the hypothesis that systemic endotoxemia plays a role in the pathogenesis of the disease.
Wieringen et al. (1976) studied this question.
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