January 1, 2016Food & Function

Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway

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Population

Human hepatocyte cell line L-02 (model of steatotic L-02 hepatocytes in vitro)

Design

Preclinical

Authors

OLOu Lv LWLifang WangCapital University JLJianke LiChinese Academy of Agricultural Sciences

Discussion

Member takes

Implication

May inform dietary polyphenol research for dyslipidemia; leaves open human translation and clinical utility.

Structured PICO

Population

Human hepatocyte cell line L-02 (model of steatotic L-02 hepatocytes in vitro)

Intervention

Purified pomegranate peel polyphenols (PPPs), punicalagin (PC), and pomegranate ellagic acid (PEA) in different concentrations

Outcome

Total cholesterol (TC) content, total bile acid (TBA) content, and relative mRNA and protein expression of PPARγ, ABCA1, and CYP7A1surrogate

Pomegranate peel polyphenols and their metabolites reduce lipid accumulation and enhance cholesterol metabolism in human hepatic cells in vitro via the PPARγ-ABCA1/CYP7A1 pathway.

Cite This Study

Lv et al. (2016) studied this question.

synapsesocial.com/papers/6a9068fe1dcd98381b840263 https://doi.org/10.1039/c6fo01261b

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Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider