Why the study?
Does a DNA vaccine encoding the EV71 VP1 gene elicit an immune response and neutralizing antibodies in mice?
Population
Female Balb/c mice aged 6-8 weeks, 19-21 gm weight (n=30)
Comparison
DNA vaccine constructs encoding EV71 VP1 gene… vs Backbone vector pVAX1 (100 μg) or PBS (100 μl)
Design
Preclinical
Follow-up
42 days
Authors
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Supports VP1 DNA vaccine pursuit for EV71; leaves open human immunogenicity and efficacy trials.
Does a DNA vaccine encoding the EV71 VP1 gene elicit an immune response and neutralizing antibodies in mice?
A DNA vaccine encoding the EV71 VP1 gene successfully elicited specific IgG and neutralizing antibodies in mice, demonstrating potential as a vaccine candidate.
Bakar et al. (2007) studied this question.
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