Experimental study demonstrates palladium-catalyzed cascade cyclization of bromoenynamides into functionalized azatricycles, highlighting a regiospecific synthetic route to the trikentrin B skeleton.
Palladium-catalyzed cascade cyclization of bromoenynamides equipped with an additional alkyne or ynamide substituent affords azatricyclic products. Using 5- to 7-membered ring tethers, this chemistry offers a regiospecific route to highly-functionalized azacycles. Elaboration to the trikentrin B skeleton is achieved from the arylsilane cyclization products.
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Campbell et al. (2013) studied this question.
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