What question did this study set out to answer?

Determine the three-dimensional structure and identify key antibody-binding epitopes of the antigenic 12 kDa excretory-secretory protein from Toxoplasma gondii.

November 27, 2012BMC Structural BiologyOpen Access

Theoretical investigation on structural, functional and epitope of a 12 kDa excretory-secretory protein from Toxoplasma gondii

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Authors

YTYap Boon Wooi TommyUniversiti Sains Malaysia TLTheam Soon LimUniversiti Sains Malaysia RNRahmah NoordinNational University of Malaysia

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Implication

Computational study models the 12 kDa excretory-secretory protein of Toxoplasma gondii, revealing a thioredoxin fold and candidate epitopes to facilitate toxoplasmosis diagnostic test design.

Key Points

Determine the three-dimensional structure and identify key antibody-binding epitopes of the antigenic 12 kDa excretory-secretory protein from Toxoplasma gondii.
Generated an in silico three-dimensional model of the uncharacterized 12 kDa excretory-secretory protein from Toxoplasma gondii.
Analyzed structural secondary elements and predicted surface epitope regions suitable for specific antibody targeting.
Predicted a thioredoxin structural fold consisting of four α-helices flanking five central β-strands.
Identified three candidate epitope regions spanning 6 to 8 residues each that coalesce into a single primary antibody-binding site.

Cite This Study

Tommy et al. (2012) studied this question.

synapsesocial.com/papers/6a9069f773c1f5e62dc930cf https://doi.org/10.1186/1472-6807-12-30

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Implication

Computational study models the 12 kDa excretory-secretory protein of Toxoplasma gondii, revealing a thioredoxin fold and candidate epitopes to facilitate toxoplasmosis diagnostic test design.

Theoretical investigation on structural, functional and epitope of a 12 kDa excretory-secretory protein from Toxoplasma gondii

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Implication

Key Points

Cite This Study

Theoretical investigation on structural, functional and epitope of a 12 kDa excretory-secretory protein from Toxoplasma gondii

Discussion

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Implication

Key Points

Cite This Study

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