Population
ALDP-deficient mice (established by gene targeting) and C57BL/6J mice; murine fibroblasts
Comparison
Transient expression of very long-chain… vs Expression of VLACS alone; normal mice
Design
Preclinical
Authors
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Clarifies ALDP's necessity for VLACS peroxisomal function; extends mechanistic insight in ALD models but leaves open human translation.
ALDP is required for the peroxisomal localization and function of VLACS in very long-chain fatty acid beta-oxidation.
Yamada et al. (1999) studied this question.
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